Archives:
Generation and Neuroprotective Studies of NF1 Patient-Derived RGCs
This work will generate RGCs from stem cells that carry NF1 mutations to better understand how changes in the NF1 gene can affect RGC survival …
Restoring Oligodendrocyte Precursor Function and Myelination in NF1 Optic Glioma
This project aims to investigate how Nf1 mutation, optic glioma, and optic glioma chemotherapy dysregulate oligodendrocyte precursor cell (OPC) function and myelination in the optic …
Novel Strategies of Protecting RGCs and their Axons in NF1 OPG Models
The objective of this project is to build on the discoveries made in Phase A, with an increased emphasis on several potentially translatable strategies for …
Optimizing Visual Recovery Using Nf1 Genetically Engineered Mice
Using a novel collection of different Nf1-mutant mouse strains engineered in the Gutmann laboratory to develop OPGs similar to those arising in children with NF1, …
Axon Regeneration and Vision Restoration in NF1 OPG
This project aims to advance candidate neuroprotective and axon regenerative therapies into proof-of-concept for safety and efficacy in NF1-OPG animal models as an essential step …
Neuroprotection and Optic Nerve Regeneration in a Mouse NF1 OPG Model
The goal of this project is to better understand NF1-OPG disease progression in two experimental mouse models and to investigate novel therapies to minimize and …
Generation and Neuroprotective Studies of NF1 Patient-derived RGCs
Neurofibromatosis type 1 (NF1) is the most common genetic condition in which individuals carrying the mutation are predisposed to develop different types of tumors. Approximately …
Structural and Functional Restoration of the Visual System in NF1
The purpose of this project is to understand the specific barriers to visual system function and optic pathway regeneration in people suffering from neurofibromatosis 1 …
New strategies of protecting RGCs and promoting optic nerve regeneration
Vision loss associated with some patients of neurofibromatosis type 1 (NF1) is characterized by degeneration of the optic nerve and the loss of retinal ganglion …
Optimizing Strategies to Improve Visual Recovery from NF1 Optic Glioma
Children with neurofibromatosis type 1 (NF1) are prone to the development of benign brain tumors that affect the optic pathway and result in vision loss. …