To facilitate the translation into clinical practices, the Zhu lab will employ two clinically relevant assays to characterize these NF1-OPG models, the optomotor response (OMR) assay for estimating visual acuity and (2) the OCT assay as an indirect estimation for axonal loss of RGCs. Following the OMR and OCT assays, the NF1-OPG models will be analyzed by histopathologic or electrophysiologic assays to determine structural or functional abnormalities caused by NF1-OPG. Further, novel therapeutic strategies for axonal regeneration will be tested on a novel NF1-OPG model with surviving RGCs.
Investigators
Yuan Zhu, PhD
Children’s National Health System
Yuan Zhu, PhD
Children’s National Health System