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Program Update

Displaying 1 – 7 of 7 Articles (1 of 1 Page)

GFF and Sage Bionetworks Collaborate on an NF1 Research Tools Database

The Gilbert Family Foundation (GFF) is excited to announce the development of a database for neurofibromatosis type 1 (NF1) research tools in collaboration with Sage Bionetworks. The database aims to support the development of a robust NF1 research toolkit while also lowering the barrier of entry to research for new-to-NF1 investigators. GFF and Sage intend the database to be used by a variety of stakeholders in the NF1 research community, including researchers, drug developers, and research funders.
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Seeking a True Cure: Developing Gene Replacement and Editing Therapies to Address the Cause of NF1

GFF's Gene Therapy Initiative seeks to explore and develop gene-targeting therapeutic strategies for neurofibromatosis type 1 (NF1) that address the underlying cause of the disease. Targeting the mutated gene itself could yield a more effective, comprehensive response for a greater range of patients.
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GFF’s Vision Restoration Initiative: Exploring Regenerative Therapies

Optic pathway gliomas (OPGs) are slow-growing brain tumors that arise in or around the optic nerve and can cause the degeneration of the optic nerve and retinal ganglion cells (RGCs) leading to vision loss. GFF's Vision Restoration Initiative aims to develop new therapies to protect and restore vision for patients affected by OPGs, including methods that address severe vision loss by regenerating RGCs and the optic nerve.
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GFF’s Vision Restoration Initiative: Exploring Neuroprotection/Neuroenhancement Therapies

Approximately 1 in 5 patients with neurofibromatosis type 1 (NF1) develop optic pathway gliomas (OPGs). These tumors can cause degeneration of the optic nerve and retinal ganglion cells (RGCs), ultimately leading to vision loss. GFF's Vision Restoration Initiative aims to develop neuroprotection/neuroenhancement therapies that protect and increase performance of injured RGCs and the optic nerve to improve visual function.
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GFF’s Guiding Values: Collaboration

The Gilbert Family Foundation (GFF) is on a mission to eradicate neurofibromatosis type 1 (NF1), but we can't do it alone. The GFF Curing NF research programs have been designed with collaboration at the core to align with other NF1 focused organizations and ensure all researchers have opportunities to share and advance together.
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Nothing Nonsensical About Nonsense Mutations: GTI Researchers Target One of the Most Common Types of NF1 Disease-Causing Genetic Mutations

While more than 1000 different mutations of the neurofibromatosis type 1 (NF1) gene have been identified to cause the disease, 1 in 5 are classified as "nonsense mutations". Several projects in GFF's Gene Therapy Initiative are exploring and identifying potential therapeutics to address NF1 nonsense mutations.
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NF Open Science Initiative – GFF’s New Partnership with Sage Bionetworks and Other NF Research Funders

The Gilbert Family Foundation (GFF) recently established a partnership with Sage Bionetworks (Sage) to enable the storage, management, and sharing of data generated by GFF-funded research.
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